type 2 diabetes mellitus and risk of malignant melanoma: a systematic review and meta-analysis of cohort studies.
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abstract
epidemiology studies have demonstrated inconsistent associations between type 2 diabetes mellitus and the risk of malignant melanoma. to this end, the aim was to perform a meta-analysis of cohort studies.medline, pubmed, embase and the cochrane library were searched up to february 2014. cohort studies addressing the relative risk of type 2 diabetes mellitus on malignant melanoma were included in this meta-analysis. the newcastle-ottawa scale was applied for quality evaluation. the pooled relative risks with the corresponding 95% confidence intervals (95% cis) were calculated by using random-effects or random-effects model. heterogeneity and publication bias were evaluated by i (2) and funnel plot analysis, respectively. data was analyzed using stata 11.0.a total of 9 independent cohorts from 8 manuscripts were entered this meta-analysis. type 2 diabetes mellitus was slightly associated with an increased risk of malignant melanoma, and the pooled relative risk was 1.15 (95% ci, 1.00-1.32) in diabetes compared with non-diabetes with significant evidence of heterogeneity among these studies (p=0.016, i (2) =57.6%). for the studies adjusted for age, gender and obesity, the relative risks were 1.21 (95% ci, 1.03-1.42), 1.17 (95% ci, 1.01-1.35) and 1.11 (95% ci, 1.00-1.24), respectively. for the population-based studies in which case cohort established, the relative risk was 1.85 (95% ci, 1.31-2.62).type 2 diabetes might be an independent risk factor for malignant melanoma. further studies are needed to specifically test the effect, and fully elucidate the underlying pathophysiologic mechanisms.
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Journal title:
iranian journal of public healthجلد ۴۳، شماره ۷، صفحات ۸۵۷-۶۶
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